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Research

What does the research say?

Research suggests that ultrasound guided radiofrequency ablation is associated with high patient satisfaction scores and long-term pain relief.

Study 1

Of 29 patients treated, 24 (83%) reported complete relief of symptoms 1 month after treatment. 17% had minimal or no relief.

(Moore, Rosen, Cohen, & Rosen, 2012).

Study 2

26 neuromas in 22 patients were treated. Pre-procedure, median pain was reported as 8/10. At 6-8 months post procedure, median pain score was 1/10

(Shah, Ahmad, Hanu-Cernat, & Choudhary, 2019).

Study 3

30 feet in 25 patients were treated. Average number of treatments required was 1.6. Average pre-procedure pain score was 6/10, dropping to 1.7/10 post procedure. Average overall symptom improvement was 76%. 10% eventually required surgery.

(Chuter, Chua, Connell, & Blackney, 2013).

Study 4

52 patients treated. Average pain score pre-procedure was 9/10. At one year, average pain score was 2/10.

(Masala, Cuzzolino, Morini, Raguso, & Fiori, 2018).

Study 5: Systematic Review and Meta-analysis

Analysis of 8 studies concluded:

  1. 83.4% of patients experienced excellent to moderate pain relief at 1 year;
  2. 16.4% experienced no benefit
  3. Incidence of complications was 2.1%, all temporary (infection, haematoma, nerve irritation).

(Llombart-Blanco, Mariscal, Benlloch, Barrios, & Llombart-Ais, 2025)

References

Chuter, G. S., Chua, Y. P., Connell, D. A., & Blackney, M. C. (2013). Ultrasound-guided radiofrequency ablation in the management of interdigital (Morton’s) neuroma. Skeletal Radiol, 42(1), 107-111. doi:10.1007/s00256-012-1527-x

Llombart-Blanco, Rafael MD, PhD; Mariscal, Gonzalo MD, PhD; Benlloch, María PhD; BLlombart-Blanco, R., Mariscal, G., Benlloch, M., Barrios, C., & Llombart-Ais, R. (2025). Systematic Review and Meta-analysis of Radiofrequency Ablation for Morton’s Neuroma: Outcomes and Predictors of Success. Am J Phys Med Rehabil, 104(5), 465-472

Masala, S., Cuzzolino, A., Morini, M., Raguso, M., & Fiori, R. (2018). Ultrasound-Guided Percutaneous Radiofrequency for the Treatment of Morton’s Neuroma. Cardiovasc Intervent Radiol, 41(1), 137-144. doi:10.1007/s00270-017-1786-y

Moore, J. L., Rosen, R., Cohen, J., & Rosen, B. (2012). Radiofrequency thermoneurolysis for the treatment of Morton’s neuroma. J Foot Ankle Surg, 51(1), 20-22. doi:10.1053/j.jfas.2011.10.007

Shah, R., Ahmad, M., Hanu-Cernat, D., & Choudhary, S. (2019). Ultrasound-guided radiofrequency ablation for treatment of Morton’s neuroma: initial experience. Clin Radiol, 74(10), 815 e819-815 e813. doi:10.1016/j.crad.2019.07.002